Simparica TRIO is a monthly chewable tablet to prevent heartworm disease, kill adult fleas, for treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections, for one month. Simparica TRIO contains sarolaner, moxidectin, and pyrantel in a flavored, chewable tablet to be given orally once per month. For dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. Chewable tablet. Sarolaner, moxidectin, and pyrantel.